自组装短肽快速止血的机制浅析
岳媛媛*1，王亮亮*2，龚剑萍2，徐晓帆1，李萌萌1，罗忠礼1
基金项目：“高等学校博士学科点专项科研基金新教师类资助课题”其项目编号为(20115503120010)支持；国家自然科学基金（NSFC）编号（81101417）支持
作者简介：岳媛媛（1989－），女，硕士研究生，主要从事临床检验，创伤修复，组织及器官再生；作者中有* 标记为共同第一作者
通信联系人：罗忠礼（1976－），男，博士，副教授，主要从事基础医学，纳米生物医学，创伤修复，组织及器官再生工程等.

（1. 重庆医科大学基础医学院；2. 重庆医科大学第一临床学院）
摘要：创伤伴随着出血和止血过程。传统的止血药物有部分局限，且不能快速止血。实验表明：自组装短肽能快速止血，除了能形成纳米相关的纳米力学效应外，更主要原因可能是形成的纳米纤维吸附(结合)了相关的离子和组织因子、凝血因子，同时激活了血小板，表明止血过程是外源性和内源性止血途径。这些研究会给创伤医学，特别是临床医学中的快速止血，带来新的临床干预办法、途径甚至药剂等。
关键词：创伤；快速止血；自组装短肽；机制
中图分类号：R817.1
Using self-assembling peptide to study the mechanism rapid hemostasis
YUE yuanyuan *1, Wang Liangliang *2, GONG jianping2, XU xiaofan1, LI
mengmeng1, LUO Zhongli1
(1. The College of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016,China;2. The College of First Clinical Medicine, Chongqing Medical University, Chongqing 400016,China)A

bstract: Trauma is always associated with blood bleeding and hemostatic process. Traditional hemostatic medicines and materials have some limitations, and they cannot stop bleeding quickly. Here, the results suggest that peptide with rapid hemostasis, is associated with not only the nanofiber foce effect, but also to the nanofibers absorbtion or intergration the corresponding ions and tisue factors, coagulation factors, speically to activated the platelet,where all confirmed the processes are due to the intrinsic pathway and the extrinsic pathway. This study could inspire the wound healing like the rapid hemostasis in clinical medicine, to produce the new strategy, therapy and beyond.
Key words: Trauma; Rapid hemostasis; Self-assembling peptide;Mechanism;