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雄激素的非基因组效应及其机制
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雄激素的非基因组效应及其机制
康林,李莎,崔慧先
基金项目:高等学校博士学科点专项科研基金(20101323120002);国家自然科学基金(31271191);河北省自然科学基金(C2012206133) 作者简介:康林,(1974-),男,副教授,神经退行性疾病的转化医学研究 通信联系人:崔慧先,男,教授,神经退行性疾病的基础研究.

(河北医科大学解剖学教研室 石家庄 050017)

摘要:雄激素具有不依赖于传统基因组途径的快速作用,这些非基因组生物学效应作用迅速,基因转译和蛋白翻译等细胞机制是非必须的,但其作用影响着个体性器官和性生理的发育和成熟,还影响性腺外诸多组织器官,如免疫系统、心血管系统和神经系统的生理活动过程。雄激素的基因组效应理论和非基因组效应理论都有各自的支持证据,两者之间存在某种交互影响,共同调节生物反应的多样性。本文综述了雄激素非基因组效应的特点和形式,以及在10 各器官组织的非基因组效应的机制,并对基因组和非基因组效应的交互影响,及其对与机体多种生理功能与病理过程的调控进行了总结与展望。
关键词:人体解剖学;雄激素;非基因组效应
中图分类号:R322

Non-Genomic Action of Androgen and Its Mechanism
kanglin, lisha, cuihuixian
(Department of Anatomy,Hebei Medical University,shijiazhuang 050017)
Abstract: Androgen’s rapid time course of action is not initially dependent on genomic mechanisms in the absence of the cellular machinery necessary for transcription/translation. Rapid  actions of androgens affect the development of gonads and the physiological activities of many tissues and organs, such as the immune system, cardiovascular system and the nervous system. The physiological effect of the non-genomic stimulation in vivo remains largely unclear. In addition, non-genomic androgen effects can function independently, or in tandem, with the other genomic effects, to initiate steroid responses. The genomic and non-genomic pathways of  androgen action are likely inter-linked and can act in concert to affect normal cell function. In the present paper, the non-genomic effects of androgens are reviewed, along with a discussion of the possible role non-genomic androgen actions have on animal physiology and behavior.
Key words: Human anatomy; Androgen; Non-genomic actions