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一种新型红细胞光电探测模型的研究
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 一种新型红细胞光电探测模型的研究
郭永彩,张小明,高潮,周森
(重庆大学光电技术及系统教育部重点实验室,重庆 400044)
摘要:本文介绍了一种新型的血红细胞光散射探测模型。该模型基于扁椭球模型和反常衍射近似理论,应用数值模拟仿真技术,分别讨论了血红细胞形体变化、体积变化、取向角和相对折射率变化对光散射幅值分布的影响并建立了相应的图谱分布,在文末对此模型进行了实验验证,结果表明在前向小角度内不同血红细胞大小、不同相对折射率对光散射信息有着较大影响。这可以在庞杂的细胞中辨别不同的细胞类型,较好的应用于细胞分类研究领域。
关键词:光散射;血红细胞;反常衍射近似;扁椭球;仿真分析;实验验证
中图分类号:TN247
A New Photoelectric Detection Model of Red Blood Cell
Guo Yongcai, Zhang Xiaoming, Gao Chao, Zhou Sen
(Key Laboratory Optoelectronic Technology and Systems of the Education Ministry of China,Chongqing University, ChongQing 400044)
Abstract: In this paper a new light scattering detection model of red blood cell was introduced. This model based on the oblate ellipsoid model and the anomalous diffraction approximation, The numerical analysis technique is applied to discuss the scattering amplitude affection of the blood cell separately, such as, in the variety of body, volume, relative refractive index and orientation angle, the dynamic relationship distribution is set up correspondingly, the model is proved by the experiment at the end of the paper. The simulation data indicate that the volume and relative refractive index of different red blood cell has the prominent effect on the scattering information in small range angle, which can help distinguish the different cell types in heterogeneous population of nucleated cells, so it can be well used in cell classification field.
Keywords: light scattering; red blood cell; anomalous diffraction approximation; oblate ellipsoid model; simulation analysis; experiment proving