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多糖分子量与胆固醇连接臂长度对胆固醇改性普鲁兰药物载体性质的影响
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多糖分子量与胆固醇连接臂长度对胆固醇改性普鲁兰药物载体性质的影响
张明明1,白永刚1,杨文智1,张其清1,2
基金项目:高等学校博士学科点专项科研基金(新教师基金)(20091106120051)
作者简介:张明明,(1978-),女,助理研究员,主要研究方向:生物医用材料,功能高分子材料。
(1. 中国医学科学院生物医学工程研究所,天津市生物医学材料重点实验室,天津 300192;2. 福州大学生物和医药技术研究院,福州 350108)
摘要:多糖引入疏水基团后,在水中能自组装形成胶束,可作为疏水小分子药物或生物活性大分子(多肽、蛋白和基因)的载体,在生物医药领域有着广泛的应用价值。本文使用胆固醇为疏水配基,琥珀酸酐和己基二异氰酸酯为连接臂,对分子量为10 万和20 万的普鲁兰多糖进行疏水改性,制备了2 种胆固醇取代度的8 种多糖样品,用其对阿霉素和米托蒽醌进行包封,考察了多糖分子量与胆固醇连接臂长度对药物包封率、形态、体外释放等性质的影响规律。
关键词:普鲁兰;药物载体;多糖分子量;连接臂
中图分类号:R318
The influence of Pullulan molecular weight and spacer length on the property of drug carriers formed by cholesterol-modified Pullulan
ZHANG Mingming1, BAI Yonggang1, YANG Wenzhi1, ZHANG Qiqing1,2
(1. Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, TianJin 300192;2. Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, FuZhou 350108)
Abstract: This kind of micelle can be used as hydrophobic drugs or bioactive molecules carriers and has potential applications in biomedical field. In this paper, using cholesterol as hydrophobic ligand, succinic anhydride and 1,6-hexyldiisocyanate as spacers, hydrophobic modified Pullulans with molecular weight about 100,000 and 200,000 were prepared. Drug-loaded nanoparticles were then prepared by dialysis method, The influence of Pullulan molecular weight and spacer length on the loading-content, morphologies and in vitro release behaviors of drug-loading nanoparticle were then investigated in detail.
Keywords: Pullulan; drug carrier; polyssacharide molecular weight; spacer