结直肠癌肝转移相关的分子标志物
陈婧，何友吉
基金项目：国家自然科学基金资助项目（81272400）; 高等学校博士学科点专项科研基金资助课题（20130092110052）
通信联系人：何友吉（1971-），女，教授，分子肿瘤.

（东南大学医学院，江苏省南京市 210009）
摘要：肝转移是结直肠癌患者死亡的主要原因。40-50%的患者在原发灶切除术后会发生肝转移。早期诊断肝转移是使患者获得根治性手术机会，得以长期生存的关键。一期或分期肝切除术是肝转移患者的首选，可切除性肝转移患者5 年生存率可达25-44％，但不可切除性肝转移患者的中位生存期不超过2 年。因此，尽早识别肝转移对于延长结直肠癌患者的生存至关重要。目前肝转移的早期诊断多依赖于影像学及定期的临床和血清学检查，这些监测手段缺乏足够的灵敏度和特异性。寻找肝转移早期诊断的新方法是当前研究的热点，本文对从患者结直肠癌原发灶、血清中寻找与肝转移相关分子标记物的研究进行总结综述，以期为结直肠癌肝转移的早期诊断提供多维度的新思路。
关键词：结直肠癌；肝转移；早期诊断；分子标记物
中图分类号：R318.14
Molecular markers predict colorectal cancer liver metastases
CHEN Jing, HE Youji
(Medical School, Southeast University, Nanjing 210009)
Abstract: Distant metastases are responsible for the great majority of colorectal cancer (CRC)deaths, mainly due to liver metastases. 40-50% of CRC patients will develop liver metastases after he surgery of primary tumor. Hepatic resection is the only potentially curative treatment for those patients. Therefore, early detection of liver metastases is of the utmost priority and can result in more radical surgery and thus long-term survival. Early diagnosis of liver metastasis is currently  more dependent on imaging and periodic clinical and serological examination, these monitoring tools lack sufficient sensitivity and specificity. Current research focus on new methods for early diagnosis of liver metastases. We review studies on molecular markers from primary tumors and sera of colorectal cancer patients and expect to provide multidimensional idea for early dignosis of
coloractal cancer liver metastases.
Key words: colorectal caner; liver metastases; early dignosis; molecular marker