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中药通过靶向细胞凋亡信号通路抗肿瘤的研究进展
来源: | 作者: | 发布时间:2014-4-15 16:09:53

中药通过靶向细胞凋亡信号通路抗肿瘤的研究进展

许焕丽,林秀坤 580
(首都医科大学基础医学院药理学系)
摘要:很多肿瘤的发生发展过程都存在凋亡异常现象。靶向凋亡信号通路已广泛被认为是肿瘤治疗的重要手段。中药在中国已应用数千年,且许多中药已被证实可有效治疗多种恶性肿瘤。随着全球肿瘤发生率的逐年升高,中药的抗肿瘤作用越来越受关注。许多研究表明,中药可通过多靶点、多途径发挥抗肿瘤作用,其中凋亡相关的靶点研究最为广泛。本文主要综585 述了几种基于凋亡途径抗肿瘤的中药,尤其是临床上具有确切抗肿瘤效果的中药,同时明确了中药作为抗肿瘤药物的瓶颈问题和发展前景。
关键词:中药;抗肿瘤;凋亡
中图分类号:R9

Antitumor effects of traditional Chinese medicine by targeting cellular apoptotic pathway
XU Huanli, LIN Xiukun
(Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University)
Foundations: Natural Science Foundation of China (no. 81302906)and Specialized Research Fund for the Doctoral Program of Higher Education(no. 20131107120019) Brief author introduction:许焕丽,1983年生,女,讲师,抗肿瘤药理学 Correspondance author: 林秀坤,1957年生,男,教授,抗肿瘤药理学.

Abstract: Defects in apoptosis are common phenomenon in many types of cancer and are also the critical step in tumorigenesis. Targeting apoptotic pathway has been considered as an intriguing strategy for cancer therapy. Traditional Chinese medicine (TCM) have been used in China for thousands of years, and many of them have been confirmed to be effective in the treatment of different 10 tumors. With an increasing cancer rate worldwide, the anti-tumor effects of TCM attracted more and more attention worldwide. Many TCM have been shown to possess antitumor effects through their multiple actions on multiple targets, and apoptosis pathway related targets are extensively studied and defined to be the most promise targets. This review focuses on several antitumor TCM especially those with clinical efficacy based on their effects on apoptotic signaling pathway. The problem and prospect 15 on TCM development as anticancer agents are also presented.
Key words: Traditional Chinese medicine (TCM); Anti-tumor effects; Apoptosis