Antitumor effects of traditional Chinese medicine by targeting cellular apoptotic pathway
XU Huanli, LIN Xiukun
(Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University)
Foundations: Natural Science Foundation of China (no. 81302906)and Specialized Research Fund for the Doctoral Program of Higher Education(no. 20131107120019) Brief author introduction:许焕丽,1983年生,女,讲师,抗肿瘤药理学 Correspondance author: 林秀坤,1957年生,男,教授,抗肿瘤药理学.
Abstract: Defects in apoptosis are common phenomenon in many types of cancer and are also the critical step in tumorigenesis. Targeting apoptotic pathway has been considered as an intriguing strategy for cancer therapy. Traditional Chinese medicine (TCM) have been used in China for thousands of years, and many of them have been confirmed to be effective in the treatment of different 10 tumors. With an increasing cancer rate worldwide, the anti-tumor effects of TCM attracted more and more attention worldwide. Many TCM have been shown to possess antitumor effects through their multiple actions on multiple targets, and apoptosis pathway related targets are extensively studied and defined to be the most promise targets. This review focuses on several antitumor TCM especially those with clinical efficacy based on their effects on apoptotic signaling pathway. The problem and prospect 15 on TCM development as anticancer agents are also presented.
Key words: Traditional Chinese medicine (TCM); Anti-tumor effects; Apoptosis
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