免疫球蛋白受体作为药物靶点的研究进展
黄琼1，陈文生2，吴育晶2，魏伟2
基金项目：高等学校博士学科点专项科研基金(20113420120006, 20123420110003)
作者简介：黄琼（1980-），女，副教授，研究方向：临床药理学
通信联系人：魏伟，男，教授，博士研究生导师，研究方向：临床药理学.

（1. 安徽医科大学临床药理研究所，合肥 230032；2. 安徽医科大学临床药理研究所,合肥 230032）
摘要：免疫球蛋白(Immunoglobulin, Ig)又称为抗体，是体内体液免疫的重要组成部分。Ig 与免疫球蛋白受体(immunoglobulin receptor, IgR)结合触发相应的生物学活性。不同的Ig 亚型有不同的生物学功能，且IgR 可作为炎症免疫相关疾病的治疗靶点，本文综述了IgR 功能及在炎症免疫相关疾病治疗与药物研究中的作用。
关键词：免疫球蛋白受体；功能；炎症；治疗
中图分类号：R967 免疫药理学
Progress in the study of a new therapeutic target:immunoglobulin receptors
HUANG Qiong1, CHEN Wensheng2, WU Yujing2, WEI Wei2
(1. Institute of Clinical Pharmacology, Anhui Medical University,Hefei, P.R. China 230032;2. Institute of Clinical Pharmacology, Anhui Medical University, Hefei, P.R. China 230032)
Abstract: Immunoglobulins (Ig), also called antibodies, are important components in humoral-mediated immunity. Ig can bind with their receptors, called immunoglobulin receptors  (IgR), trigger biologic activity respectively. Different subtypes of Igs show different function. And IgRs have been treated as therapeutic targets in inflammation and immunity related diseases for many years. This article reviewed the recent progresses in the study of IgR function and its therapeutic role in inflammation and immunity related diseases.
Key words: immunoglobulin receptor; function; inflammation; therapy