组蛋白修饰与DNA 及microRNA 甲基化在胃癌中的研究进展
刘剑，戴冬秋
基金项目：Higher Specialized Research Fund for Doctoral Program of Ministryof Education of China
(#20102104110001).
作者简介：刘剑（1984-），男，住院医师，胃癌的表遗传学研究
通信联系人：戴冬秋，（1963-），男，教授，胃癌的表遗传学研究. 

 （中国医科大学附属四院胃肠外科，沈阳 110032）
摘要：表遗传学修饰在胃癌的发生、发展中起重要作用,组蛋白修饰与DNA 甲基化及microRNA 甲基化作为表遗传学的重要组成部分已成为研究的热点.大量研究发现蛋白修饰与DNA 甲基化及microRNA 甲基化在胃癌中分别发生了不同程度的改变， 这种变化
具有重要的临床价值，可能成为判断肿瘤生物学特性及临床预后的重要指标之一。本文就与胃癌相关的组蛋白修饰与DNA 甲基化及microRNA 甲基化研究进展作一综述.
关键词：胃癌； DNA 甲基化；组蛋白修饰；microRNA 甲基化
中图分类号：请查阅《中国图书馆分类法》
 Advances in Study on Histone Modification and Methylation of DNA and microRNA in Gastric Cancer
LIU Jian, DAI Dongqiu
(Department of Gastrointestinal Surgery,the Fourth Affiliated Hospital,China Medical University, Shenyang 110032)
20 Abstract: Histone modification and methylation of DNA and microRNA, as important components of epigenetics that plays vital role in the development and progress of gastric cancer, has become a research hotspot. Accumulating studies have demonstrated that changes in Histone modification and methylation of DNA and microRNA occurred in gastric cancer, having significant value in clinical practice and May become the judge one of the important indexes of tumor 25 biological characteristics and clinical outcome.This article reviewed the recent advances in study on Histone modification and methylation of DNA and microRNA in gastric cancer.
Key words: gastric cancer; Histone Modification; DNA Methylation; microRNA Methylation