归附痛经颗粒对寒凝血瘀证模型大鼠血液流变性的影响
于瑞红，曹蕾
作者简介：于瑞红（1990-），女，硕士生，主要研究方向：血管药理学
通信联系人：曹蕾（1985-），女，讲师，主要研究方向：血管药理学.

（西安交通大学医学院药理学系）
摘要：目的 观察归附痛经颗粒对寒凝血瘀证模型大鼠血液流变性的影响。方法 制作急性寒凝血瘀证大鼠模型，用归附痛经颗粒灌胃1 周，取血检测全血黏度和还原粘度、红细胞变形指数和刚性指数、红细胞压积、血浆黏度、纤维蛋白原及血沉。结果 与正常组比较，模型组全血黏度、还原黏度、红细胞刚性指数明显升高（P＜0.05 或P＜0.01）；与模型组比较 0.5g/kg 和1.0g/kg 剂量的归附痛经颗粒能降低血瘀大鼠全血高切粘度、全血低切粘度和低切还原粘度（P＜0.01）。结论 归附痛经颗粒能改善寒凝血瘀证大鼠的血瘀状态。
关键词：药理学；归附痛经颗粒；寒凝血瘀证；血液流变性
中图分类号：R965.1
The effect of Guifu tongjing granula on hemorheology of congealing cold and blood stasis rats
YU Ruihong, CAO Lei
(Department of Pharmacology,Xi'an Jiaotong University School of Medicine ,Xi'an 710061)
Abstract: Objective:To observe the effect of Guifu tongjing granula on hemorheology of  congealing cold and blood stasis rats. Method:Make model of congealing cold and blood stasis in rats,intragastric administration Guifutongjing granula for 1 week,collect blood by abdominal aortic method and determine blood specific and reductive viscosity , erythrocyte deformation index and rigid index, hematocrit, plasma viscosity, fibrinogen and erythrocyte sedimentation rate.
Result:Compared with normal group,blood specific and reductive viscosity, erythrocyte rigid index of model group increased greatly(P＜0.05 or P＜0.01); compared with model group,0.5g/kg and 1.0g/kg group of Guifu tongjing granula reduce high-shearrate blood
viscosity ,low-shearrate blood viscosity and low-shearrate reductive viscosity(P ＜ 0.01).
Conclusion:Guifu tongjing granula can improve the blood stasis state of congealing cold and
blood stasis rats .
Key words: pharmacology;Guifu tongjing granula;syndrome of congealing cold and blood stasis;hemorheology