小鼠膀胱癌原位瘤动物模型建立方法的研究进展
宋玲玲1,2，金巡2，张佩兰2，程舟礼2，程浩2，苟马玲1,2
作者简介：宋玲玲，1988，女，研究生，肿瘤学
通信联系人：苟马玲，1985，男，副研究员，肿瘤生物治疗基础研究. 

 （1. 四川大学华西医院肿瘤中心；2. 四川大学生物治疗国家重点实验室，成都，610041）
摘要：动物模型是研究疾病发生、发展机理与临床前药效评价的重要工具。膀胱癌是最常见的泌尿系统恶性肿瘤，急需发展新的治疗手段，建立原位膀胱癌模型对研究新型膀胱癌治疗手段非常重要。小鼠原位膀胱癌模型是常用的膀胱癌模型,目前的建立方法主要分为诱导法和移植法两大类,本文将综述小鼠原位膀胱癌模型的建立方法。
关键词：原位膀胱癌；动物模型；小鼠
中图分类号：R737.14
Advance of methods to set orthotopic bladder cancer model in mice
SONG Lingling1, JIN Xun2, ZHANG Peilan2, CHENG Zhouli2, CHENG Hao2, GOU Maling1
(1. State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,West China Medical School,Sichuan University,Chengdu 610041;2. State Key Laboratory of Biotherapy,Sichuan University,Chengdu 610041)
Abstract: Animal models are important means for studding the mechanism of diseases occurrence, disease development, and evaluating the potency of drug candidate in preclinical.Bladder cancer is the most common malignant tumor of urinary system, and new methods for bladder cancer therapy are requested. It is of great importance to set orthotopic bladder cancer model for new bladder cancer treatment. Setting orthotopic bladder cancer in mice has the certain difficulty. There are two major methods, derivative method and transfer technique. This article will summarize the methods to set orthotopic bladder cancer model.

Key words: orthotopic bladder cancer; animal model; mice