智能磁共振成像造影剂的研究进展
钱玉娥1，王天宇2，唐建斌2
（1. 浙江大学医学院附属邵逸夫医院放射科，杭州 310027；2. 浙江大学生物纳米工程中心，化学工程与生物工程学系，杭州 310027）
摘要：智能MRI 造影剂能够对特定或者病变的一些信号如pH、金属离子、酶、其他生物分子做出响应，改变其弛豫率。它们不仅能够提高MRI 对病变的检测灵敏度，而且能够针对病变的信号分子进行分子成像。本项详细综述了pH、金属离子、酶、其他生物分子等响应的智能造影剂，分析了他们的结构和响应机制及其应用前景，并对未来的研究方向做了展望。
关键词：磁共振成像；造影剂；钆配合物；疾病诊断
中图分类号：O6-1
Research Progress in Smart MRI Contrast Agent
Qian Yue1, Wang Tianyu2, Tang Jianbin2
(1. Department of Radiology, Sir Run Run Shaw Hospital (SRRSH) of School of Medicine,Zhejiang University, HangZhou 310027;2. Department of Chemical and Biological Engineering, Center for Bioengineering, Zhejiang University, HangZhou 310027)
Abstract: Smart magnetic resonance imaging (MRI) contrast agents change their relexivities upon the stimulus of pH, ion, enzyme and other biomolecules from specific or pathologic tissues. They not only improve the sensitivity of disease detection by MRI, but also make the molecular imaging of disease signal by MRI possible. This paper gives a review of smart MRI contrast agents responding to pH, ion, enzyme and other biomolecules with the focus on their structures,responding mechanism, and perspectives.
Keywords: Magnetic resonance imaging; Contrast agent; Gadolinium complexes; Disease diagnosis