尿素通道蛋白B的转运特性
钟丹丹，杨宝学
基金项目：国家自然科学基金(No.30870921，81170632，81261160507)、科技部国际科技合作与交流专项（No.2012DFA11070）、教育部高等学校博士学科点专项科研基金(No.20100001110047) 作者简介：钟丹丹(1990)，女，硕士研究生，药理学 通信联系人：杨宝学，男，教授，药理学.

（天然药物及仿生药物国家重点实验室，北京大学基础医学院药理学系，北京，100191）

摘要：尿素通道蛋白B（urea transporters B, UT-B）主要表达在红细胞和一些上皮及内皮细胞膜，介导尿素的跨膜转运。近年来研究发现UT-B亦参与其他物质的转运，如水、NH3和尿素类似物等，提示UT-B还可以作为水和气体通道。本文主要阐述UT-B对这些物质的转运特性，并探究其可能的生理学意义。
关键词：尿素通道蛋白B；尿素；尿素类似物；NH3；水
中图分类号：R96
Transport characteristics of urea transporter-B
Zhong Dandan1,2, Yang Baoxue1,2
(1. State Key Laboratory of Natural and Biomimetic Drugs; 15 2.
Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China, 100191)
Abstract: Urea transporter UT-B is highly expressed in the membrane of erythrocytes and some epithelial and endothelial cells, in which UT-B facilitates urea transport. Recently, studies found that 20 water, ammonia and urea analogues can also be transported by UT-B. This review mainly focus on the transport characteristics of UT-B, and the possible physiological significance will be discussed as well.
Key words: UT-B; urea; urea analogues; ammonia; water